Tuesday, 23 August 2011

Toxic antibodies blitz tumours

"On 19 August, the US Food and Drug Administration (FDA) approved the company's lead therapy, an antibody engineered to deliver a poisonous payload directly into lymphoma cells. The hope is that such antibodies, called antibody–drug conjugates, will sidestep the punishing toxicities of classical chemotherapies, which run loose in the bloodstream and kill healthy cells in addition to their targets."


"Seek and Destroy" -Functionality of antibody-drug conjugates as described in the article by Heidi Ledford. "Their power comes from their payloads: lethal drugs tethered to the antibody that remain harmless until the conjugate releases them inside cancer cells" 


"In July, an FDA advisory committee voted unanimously in support of accelerated approval for Adcetris after Seattle Genetics reported that 94% of the 102 people with Hodgkin's lymphoma in a trial of the treatment saw their tumours shrink, and 73% achieved partial or complete remission."


Extracts from the article "Toxic antibodies blitz tumours".  Published online 22 August 2011.  Nature.com.  To read the full article click the link in the title or use:
http://www.nature.com/news/2011/110822/full/476380a.html





Monday, 22 August 2011

3-Way (The Golden Rule) (feat. Justin Timberlake & Lady Gaga)


Absolutely hilarious! Love The Lonely Island. Click the title for a link to their website (and even more tracks).

Warning - This video should probably not be viewed by those under the age of 15 (if not older) as it contains explicit lyrics. L&TAP accepts no responsibility for any offence caused by this video.

Thursday, 18 August 2011

Marley & Me Movie Trailer



I spent 3 years at least building myself up to watch this movie. We've all heard how sad it is, especially for someone so crazy in love with their pet dog as I am with Indiana.

Well I'm not going to lie. Yes this movie is sad. Yes I cried like a baby, and yes it took me nearly an hour to compose myself afterwards and another 2 days to stop cuddling Indie every time he came near me (much to his disgust I'm sure!). Putting all that aside, Marley and Me was one of the best movies I have seen this year.

It may be a bit girlie but if you love dogs (even half as much as I do) then there is nothing not to love about this film.

I literally laughed out loud at clearance puppies antics, as they reminded me so much of those of my own clearance puppy.

In short, if you think you can cope with the fact that you WILL cry after watching this film then it really is a must see. I cannot recommend it enough and only wish I had seen it sooner myself so I could have even more time to watch it again and again as I am now sure to do.

Wednesday, 17 August 2011

The waking nightmare of sleep paralysis


I just came across this article written by Chris French and published in the Guardian in 2009.
I have recently discovered sleep paralysis as a condition and it has put an end to my constant wondering about the weird kind of dreams I have and how messed up my head must be!  
In a way it's a relief to know I'm almost normal in the sense of having such a condition but as this account from a fellow sufferer illustrates, I am far from comfortable going to sleep at night with exactly the same experiences possibly awaiting me as Ms Ball.

...This is illustrated by an account from Lori Ball, a healthy 53-year-old woman from Ohio who is not only well-informed about sleep paralysis but is actually cognisant of what is happening to her while it's happening: "I try to scream (though I have great difficulty making any sound), attempt to flail around, anything, to get the attention of my husband. It is a feeling of panic, entrapment and desperation so horrifying that I have difficulty describing its magnitude.
"If my spouse notices my discomfort and responds, in my mind it's never soon enough. One cannot simply tell me to 'wake up' and tap me on the arm. Often I need to be shaken somewhat to be fully present. At that point I wouldn't care if he slapped me hard as the terror of being in that paralysed state, totally helpless, is overwhelming. Knowing that it will end eventually is of no comfort. Every second is hell."
To see the article in full please click the link in the post title.

Saturday, 13 August 2011